Being on the faculty of the Institute of Functional Medicine is a rewarding part of my professional life. On Sunday, I returned from an intense weeklong meeting with other members of the faculty and leadership of the Institute for Functional Medicine.  I’m excited to report that we brought the Functional Medicine Health Matrix (for diagnosis and treatment) protocol to a new level. One of the things that is so exciting about this is that this proceeds from the same structural premise found in THE age-old Eastern approaches to health.  Thus, the Matrix is a marriage of the old and the new and has significant treatment implications. While the new Matrix will not be rolled out for a year to new practitioners, faculty physicians, such as myself, will be using the new Matrix immediately. We anticipate lowering health care costs and improving health outcomes to our patients using this new Matrix.
 
In addition to the faculty and leadership meeting, I attended a Functional Medicine Detoxification Education Module, which featured the latest data regarding chemical and environmental toxicity [we are all facing increased levels of toxicity], and various protocols to detoxify ourselves.

Let me start by acknowledging what is well known: Manic Depression or Bipolar disorder can be a devastating illness. Affecting at least 1% of the population, it can, untreated, result in suicide, ruined careers and devastated families. Bipolar disorder is often accompanied by alcohol and drug abuse and addiction, criminal and even violent behavior. I acknowledge this, because I do not want to make light of the burden this illness places on people’s lives, their families and communities.

On the other hand, the history of the world has been influenced very significantly by people with manic depression (see my website www.wholepsychiatry.com for details)-from actors and actresses (Patty Duke, Jim Carey and Robin Williams) to Politicians (Winston Churchill, Theodore Roosevelt) to astronauts (Buzz Aldren), media mogels (Ted Turner) and perhaps even well known religious figures.

It seems clear that for at least some people with Bipolar disorder, there is an increased sense of spirituality, creativity, and accomplishment. It may be that having bipolar disorder holds great potential, if one is able to master or effectively channel the energies, which are periodically available, to some higher task. This would of course presume the ability to abstain from harmful drugs and alcohol, to have good character, and at least some supportive relationships and community networks.

It might be helpful to consider a reconceptualization. Perhaps instead of it being a disorder, we can think of people with bipolarity as having access to unusual potency. This potency will find a way to be outstanding-either in a destructive way, or in a constructive way. If such a choice is presented to the person, perhaps it can open some doors.

I will be discussing this and other aspects of bipolar disorder on Wednesday, August 4th @ 12PM Eastern time in my free virtual teleconference.

In a previous blog, I talked about how many doctors and patients do not know the full story about their drugs or medical treatments because of a widespread problem involving unpublished or biased clinical trials. Here is an update on what is happening.

As I mentioned, frequently, medical journals or pharmaceutical companies that sponsor research will report only positive results, leaving out the non-findings or negative findings where a new drug or procedure may have proved more harmful than helpful.

“A new review of research about this problem points to hidden or misleading studies for all sorts of conditions, including depression, Alzheimer's disease, type 2 diabetes, menopausal symptoms and cancer”, said Beate Wieseler, deputy head of the Institute for Quality and Efficiency in Health Care (IQWiG) Drug Assessment Departmentresearchers at in Germany.

Much of that problem arises from financial conflicts of interest when pharmaceutical or medical device companies fund the studies, according to Wieseler and her colleagues.  They pointed to past research showing an association between industry sponsorship and positive outcomes or conclusions in studies.  The FDA currently does not disclose much of the information it receives from companies when deciding what drugs or devices to approve for market. Now Wieseler and her colleagues want a global system to register trials and make public all research results for drugs or other medical interventions.  They detailed their findings in the April issue of the journal Trials.

"It's been shown that reporting bias is associated with all sorts of funding – government funding, department funding, industry funding – but the worst source of bias is industry-funded," said Kay Dickersin, an epidemiologist at Johns Hopkins University in Baltimore.

The FDA's European counterpart, the European Medicines Agency, has also considered its own steps toward more disclosure. "The agencies understand that there's a need for more transparency," Wieseler said. "There is increasing understanding that the public should have access [to clinical trial data]."
But regulatory agencies still have not decided how to balance the need for public access against the desire by companies to keep commercial information or trade secrets confidential, Wieseler noted.

As a post script…

In the above we see the overlapping territory of medicine, government, and politics. I encourage people to be proactive in improving and protecting their health. Here is an opportunity to do so.

There are over 900 'new to nature' chemicals in our environments, in our blood, and many are even in the blood of unborn children. Now, following the heightened concern regarding bisphenol A (in clear plastics, such as baby bottles), the FDA is beginning to set its sights on Triclosan. Triclosan is an antibacterial preservative used in "76% of liquid soaps and 29% of bar soaps". Aside from soaps, triclosan is also used in toothpastes, cosmetics, shoes, socks, workout clothes, and many personal care products. Triclosan has been detected in the urine of 75% of Americans, 60% of US streams, and persists in the environment for at least 40 years.

"Animal studies have shown that triclosan alters hormone regulation" according to the FDA, and there is no benefit to using soaps containing this chemical. Despite the fact that the European Union will prohibit its use in products that come into contact with food beginning next year, the FDA states that it "does not have sufficient safety evidence to recommend changing consumer use of products that contain triclosan at this time." The last time I checked, we were part of the animal kingdom. It seems reasonable to conclude that there is a possibility that this chemical is part of the cause of the national epidemic of hormonal dysfunction (e.g, hypothyroidism). While the FDA is advising no change in regulation or consumer behavior until there is evidence that triclosan is harmful to humans, such studies could take years. Additionally, studies which can determine the synergistic effect of this chemical in combination with other new-to-nature concoctions will, in all likelihood, never be done.

Given the facts that a) animal studies show an effect of triclosan on thyroid function (reduction in thyroxine, testosterone and sperm counts in rats), b) triclosan is toxic to aquatic animals and plants and c) there is no benefit to using the product , I advise you to seek out products that are free of triclosan.

These products can be found at IKEA, the Body Shop, Whole Foods and Trader Joes (read the labels!).  Brands that do not use triclosan include Ivory, Tom's of Maine, Listerine Essential Care, Peelu, Weleda, Toxic Free Basics, Aveda, Clean Well, LUSH, Nature's Gate, Vermont Country, Paul's Organic, Dr Bronner's Magic Soaps, MiEssence, The Natural Dentist.

For more information, visit http://www.fda.gov/forconsumers/consumerupdates/ucm205999.htm

Yours in health,
Dr. Robert Hedaya